Apolipoprotein E4, amyloid, and cognition in Alzheimer's and Lewy body disease
نویسندگان
چکیده
منابع مشابه
Cognition and Lewy body disease.
INTRODUCTION We're assisting in last years to an important change in clinical manifestations of Parkinson disease. Nowadays motor symptoms have best treatments if we compare with those existing some decades ago, which in last term, permits other manifestations being the main disabilities in an advanced Parkinson disease. Among these disabilities cognitives are the most severe due to it's preval...
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BACKGROUND The apolipoprotein E (APOE) ε4 allele has been reported to be a risk factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Previous neuropathological studies have demonstrated similar frequencies of the APOE ε4 allele in AD and DLB. However, the few ante-mortem studies on APOE allele frequencies in DLB have shown lower frequencies than post-mortem studies. One reas...
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Tadafumi Hashimoto,1 Alberto Serrano-Pozo,1 Yukiko Hori,1 Kenneth W. Adams,1 Shuko Takeda,1 Adrian Olaf Banerji,1 Akinori Mitani,1 Daniel Joyner,1 Diana H. Thyssen,1 Brian J. Bacskai,1 Matthew P. Frosch,1 Tara L. Spires-Jones,1 Mary Beth Finn,2 David M. Holtzman,2 and Bradley T. Hyman1 1Department of Neurology, Alzheimer’s Disease Research Unit, Massachusetts General Hospital, Charlestown, Mass...
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متن کاملApolipoprotein E4 and Alzheimer's disease in São Paulo-Brazil.
Several recently published studies showed the existence of an association between the allele epsilon 4 of the apolipoprotein E and Alzheimer's disease (AD) in developed countries. We examined this association in 55 patients with possible or probable AD and 56 elderly controls referred to outpatient clinics at the "Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo" and ...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2021
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2021.06.004